2012年4月20日星期五

Information of Heparin Sodium




Product name:Heparin Sodium
Description of Heparin Sodium:
Heparin Sodium, is a heterogenous group of straight-chain anionic mucopolysaccharides, called glycosamino-glycans having anticoagulant properties. Although others may be present, the main sugars occurring in heparin are:
(1) α- L-iduronic acid 2-sulfate,
(2) 2-deoxy-2-sulfamino-α-D-glucose-6-sulfate,
(3) β-D-glucuronic acid,
(4) 2-acetamido-2-deoxy-α-D-glucose,
(5) α-L-iduronic acid. These sugars are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions. The potency is determined by a biological assay using a USP reference standard based on units of heparin activity per milligram.
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